Table 2.
Comparison of controls and TLR4 SNP rs4986790 cases divided by BMI Quartiles
| Controls (n = 2698) | Cases (n = 319) | |||||||
|---|---|---|---|---|---|---|---|---|
| BMI, quartiles | Q1 | Q2 | Q3 | Q4 | Q1 | Q2 | Q3 | Q4 |
| Number, n (%) | 665/754 (88,2) | 674/756 (89,2) | 676/752 (89,9) | 683/755 (90,5) | 89/754 (11,8) | 82/756 (10,8) | 76/752 (10,1) | 72/755 (9,5) |
| Age, y | 56,7 ± 9,4 | 57,4 ± 9,2 | 57,0 ± 8,6 | 57,0 ± 8,9 | 55,2 ± 10,1 | 58,7 ± 8,0 | 57,3 8,1 | 57,6 ± 9,2 |
| Sex, female n (%) | 239 (36) | 128 (19) | 135 (20) | 191 (28) | 33 (37) | 14 (17) | 23 (30) | 18 (25) |
| BMI, kg/m2 | 22,6 ± 1,7 | 25,8 ± 0,7 | 28,2 ± 0,8 | 32,7 ± 3,0* | 22,6 ± 1,7 | 25,8 ± 0,6 | 28,1 ± 0,7 | 33,0 ± 3,3* |
| Smoking, n (%) | 300 (45) | 317 (47) | 331 (49) | 314 (46) | 44 (49) | 38 (46) | 31 (41) | 31 (43) |
| Diabetes, n (%) | 80 (12) | 81 (12) | 68 (10) | 134 (20)* | 10 (11) | 12 (15) | 17 (22) | 11 (15) |
| Cholesterolemia, n (%) | 337 (51) | 393 (58) | 379 (56) | 410 (60)* | 50 (56) | 51 (62) | 41 (54) | 40 (56) |
| LDL, mg/dl | 122,1 ± 40,0 | 126,5 ± 40,8 | 126,5 ± 41,8 | 122,9 ± 41,5 | 126,7 ± 39,3 | 124,7 ± 36,8 | 116,2 ± 36,5 | 118,1 ± 30,2 |
| HDL, mg/dl | 55,3 ± 33,4 | 49,7 ± 16,3 | 47,2 ± 16,0 | 45,4 ± 13,2* | 54,4 ± 16,0 | 48,1 ± 13,5 | 44,2 ± 11,7 | 44,6 ± 10,7* |
| TG, mg/dl | 137,3 ± 139,0 | 154,4 ± 111,7 | 171,0 ± 104,5 | 198,1 ± 195,8* | 116,7 ± 62,2 | 184,0 ± 105,0 | 158,6 ± 121,9 | 198,9 ± 156,7* |
| SBP, mmHg | 144,7 ± 26,6 | 144,4 ± 25,5 | 145,2 ± 25,4 | 148,5 ± 26,3* | 143,3 ± 28,1 | 146,6 ± 23,6 | 144,4 ± 26,0 | 141,5 ± 24,2# |
| DBP, mmHg | 79,4 ± 3,6 | 79,7 ± 3,8 | 79,6 ± 3,6 | 79,8 ± 3,5 | 80,0 ± 3,9 | 79,6 ± 2,6 | 79,3 ± 5,4 | 79,1 ± 4,6 |
| PP, mmHg | 64,9 ± 25,6 | 65,2 ± 25,3 | 65,8 ± 25,8 | 68,8 ± 26,1* | 62,8 ± 27,8 | 66,8 ± 24,6 | 65,7 ± 25,6 | 61,2 ± 22,8# |
| Hypertension, n (%) | 359 (54) | 380 (56) | 386 (57) | 417 (61)* | 42 (47) | 49 (60) | 40 (53) | 37 (51) |
| Antihypertensive drugs, n | 1,15 ± 1,08 | 1,24 ± 1,08 | 1,31 ± 1,07 | 1,48 ± 1,10* | 1,05 ± 1,01 | 1,32 ± 1,00 | 1,32 ± 0.97 | 1,23 ± 1,04 |
| HR, bpm | 75,2 ± 12,5 | 73,4 ± 12,7 | 73,6 ± 12,7 | 73,7 ± 12,6 | 75,3 ± 12,5 | 74,2 ± 11,6 | 75,3 ± 11,6 | 72,8 ± 12,3 |
| MI, % | 441 (66) | 504 (75) | 493 (73) | 477 (70) | 53 (60) | 57 (70) | 55 (72) | 53 (74) |
Data are presented as mean ± SD; other variables are presented as number (%), Q1-Q4: quartile 1-4, BMI quartile ranges: Q1: BMI < 24,64, Q2: BMI ≥24.65-26,89, Q3: BMI ≥ 26. 26.90-29.50, Q4: BMI ≥ 29,51, BMI body mass index, LDL low-density lipoprotein, HDL high-density lipoprotein, TG triglycerides, SBP systolic blood pressure, DBP diastolic blood pressure, PP pulse pressure, HR heart rate, MI myocardial infarction, *P for trend <0.05, # P < 0.05 controls versus TLR4 SNP rs4986790 cases