Figure 3.

Frequencies of genetic alterations affecting the receptor-JAK-STAT axis among hematologic malignancies. Diagrams give an overview of the maximal overall frequency of cases with genetic alterations of the receptor-JAK-STAT axis in (A) myeloid lineage, (B) lymphoid progenitors and (C) lymphoid mature cells disorders (see next page). The overall frequency (i.e. the sum of the individual mutation frequencies for each component among the different references) is indicated in yellow while the absolute contributions of each are detailed using a specific color code (yellow for JAK1, orange for JAK2, green for JAK3, turquoise for TYK2, pink for cytokine receptors, black for STAT3, red for STAT5b and gray for STAT6). Schematic protein representations are used to localize the identified point mutations with the affected functional domains indicated in red. In some cases, other genetic lesions and clinical associations are described. MPN: myeloproliferative neoplasms; PV: polycythemia vera; ET: essential thrombocythemia; MF: myelofibrosis; CNL: chronic neutrophilic leukemia; CML: chronic myeloid leukemia; JMML: juvenile myelomonocytic leukemia; AMKL: acute megakaryoblastic leukemia; ALL: acute lymphoblastic leukemia; DS: Down-syndrome; T-PLL: T-prolymphocytic leukemia; ATLL: adult T-cell lymphoma; NKTCL: NK/T-cell lymphoma; NK- and T-LGL: NK-and T-large granular lymphocytic leukemia; PMBL: primary mediastinal B-cell lymphoma; HL: Hodgkin lymphoma. For abbreviations and explanations see footnote.