Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Oct;100(10):1267–1274. doi: 10.3324/haematol.2015.129239

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright© Ferrata Storti Foundation

PMC Copyright notice

Figure 1. — Tert activation by testosterone in vitro. (A) Fold change of Tert mRNA in murine bone marrow cells treated with testosterone or estradiol at indicated concentrations. (B) Fold change of Tert mRNA in MEF treated with testosterone or estradiol at indicated concentrations. (C) Fold change of Tert mRNA in murine bone marrow cells treated with testosterone and testosterone in combination with 1 μM 4-hydroxytamoxifen. (D) Fold change of Tert mRNA in MEF treated with testosterone and testosterone in combination with 1 μM 4-hydroxytamoxifen. (E) Fold change of Tert mRNA in Tert^+/+ and Tert^+/− bone marrow cells. Tert^+/− cells were incubated with testosterone and testosterone in combination with 1 μM 4-hydroxytamoxifen. (F) Fold change of Tert mRNA in Tert^+/+ and Tert^+/− MEF. Tert^+/− cells were incubated with testosterone and testosterone in combination with 1 μM 4-hydroxytamoxifen. All graphs show mean values, error bars indicate SEM, n = number of samples from different mice or MEF clones. A one-sided Student t-test was used for the statistical analysis. P-values are indicated. n.s. = not significant. (G) Illustration of putative binding sites for the estrogen receptor (ERE) and the Sp1 transcription factor in the promoter region of the mouse Tert gene.