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Effect of combining msh2Δ and rad27Δ on lys2::InsE-A8 mutation rate
The strains are isogenic to E35 (wild type) and were prepared using the lithium acetate/PEG/DMSO transformation method. 95% confidence intervals are in parentheses.
| Genotype |
lys2::InsE-A8 mutation rate |
|
|---|---|---|
| Absolute rate (×10−8) | Relative rate | |
| Wild type | 1.6 (1.4–4.2) | 1 |
| msh2Δ | 750 (640–970) | 460 |
| rad27Δ | 110 (76–160) | 68 |
| msh2Δ rad27Δ | 21,000 (17,000–27,000) | 13,000 |
