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Effect of dna2-1 msh2Δ on his7-2 mutation rate
The strains are isogenic to E134 (wild type) and were prepared using the lithium acetate/PEG/DMSO transformation method.
| Genotype |
his7-2 mutation ratea |
|
|---|---|---|
| Absolute rate (×10−8) | Relative rate | |
| Wild type | 0.8 (0.5–1.7) | 1 |
| dna2-1 | 8 (4–10) | 10 |
| msh2Δ | 120 (100–140) | 160 |
| dna2-1 msh2Δ | 280 (260–400) | 340 |
a The mutation rates were measured at 25 °C. 95% confidence intervals are in parentheses.
