FIGURE 2.

High resolutions structures of eIF4F components. A, a graphic representation of the interactive domains of eIF4F and the two-domain structure of eIF4A. PAM, PABP-interacting motif. B, clockwise, a selection of a few high resolution structures that represent eIF4A·AMP·eIF4FG HEAT domain in the open confirmation (Protein Data Bank (PDB): 2VSO (40)), the closed confirmation of eIF4AIII as it exists in the exon junction complex with ADPNP (PDB: 2HYI (86)), the structure of the C-terminal HEAT-2 and HEAT-3 domains in eIF4G (PDB: 1UG3 39)), the N-terminal PABP binding domain of eIF4G with PABP·poly(A) (PDB 4F02 (87)), and a solution structure of m⁷GTP·eIF4E bound to eIF4G (PDB: 1RF8 (88)). Note that the colors of the domains in the structures are coded to those as seen in the graphic in panel A. This figure is used with the generous permission of Dr. Christopher Fraser, University of California at Davis, and with permission from Elsevier Publishing. This figure can be found in Ref. 89.