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HDX-MS kinetics of peptic fragments of ataxin-3(Q64) and alanine-scanning mutants. A, peptic regions of the Josephin domain in which alanine-scanning mutations decreased HDX-MS kinetics are shown as spheres at backbone amide positions (PDB code 1YZB (22)). B–H, peptic fragments 34–57 (B), 62–74 (C), 75–102 (D), 134–163 (E), 143–163 (F), 151–163 (G), and 164–177 (H) represented in comparison with wild-type ataxin-3(Q64) (black), and ataxin-3(Q15) (gray).
