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Helix-α4 forms the core of the first-stage fibril. A and B, TEM micrograph of the Josephin domain fibrils before (A) and after (B) digestion with proteinase K. Scale bar equals 100 nm. Mass spectrometry of the digested Josephin domain fibrils identified residues 76–89 (helix-α4) as the core of the first-stage fibril.
