FIGURE 9.

Schematic illustrating the role of MG53 in wound healing and scar formation. a, MG53 nucleates the cell membrane repair machinery and protects against acute injury to keratinocytes and fibroblasts in response to dermal injury. b, MG53 promotes the migration of fibroblasts to the wound sites by modulating stress fiber formation. c, MG53 regulates TGF-β/Smad signaling to control the differentiation of fibroblasts into myofibroblasts, leading to down-regulation of ECM proteins during the tissue remodeling process of wound healing.