Table 2a.
Previously reported genes linked to 116 dB SPL noise exposure
| Symbol | Gene title | Fold-change | P | Reference ID |
|---|---|---|---|---|
| Transcriptional regulators | ||||
| Fosa*,b*,d | FBJ osteosarcoma oncogene | 5.6 | 0.0002 | AV026617 |
| Egr1a*,b* | Early growth response 1 | 4.7 | 0.0001 | NM_007913 |
| Nr4a3b | Nuclear receptor subfamily 4, group A, member 3 | 3.5 | 0.0005 | BE692107 |
| Nr4a1b* | Nuclear receptor subfamily 4, group A, member 1 | 3.3 | 0.0001 | NM_010444 |
| Atf3b* | Activating transcription factor 3 | 3.1 | 0.0001 | BC019946 |
| Junb | Jun oncogene | 1.6 | 0.0164 | NM_010591 |
| Zfp36b | Zinc finger protein 36 | 1.5 | 0.0075 | X14678 |
| Oxidative and inflammatory stress response | ||||
| Dusp1b* | Dual specificity phosphatase 1 | 2.0 | 0.0002 | NM_013642 |
| Dusp5b* | Dual specificity phosphatase 5 | 1.7 | 0.0015 | BB442784 |
| Ptgs2b* | Prostaglandin-endoperoxide synthase 2 | 1.6 | 0.0014 | M94967 |
| Pvrb | Poliovirus receptor | 1.4 | 0.0226 | BB049138 |
| Cell cycle/differentiation | ||||
| Btg2a*,b | B-cell translocation gene 2 | 1.6 | 0.0156 | NM_007570 |
| Btg2a*,b | B-cell translocation gene 2 | 1.6 | 0.0289 | NM_007570 |
| Gdf15b* | Growth differentiation factor 15 | 1.2 | 0.0299 | NM_011819 |
a
Prior NIHL study = 90 min noise exposures (PTS and TTS), 2.0-fold-changes; no FDR utilized (Cho et al. 2004),
b
Prior NIHL study = Impulse noise, 2.0-fold changes (P < 0.008), FDR = 0.25 (Kirkegaard et al., 2006),
c
Salicylate ototoxicity = 2-fold up-regulation; no FDR utilized (Im et al., 2007)
d
Prior NIHL study = 90 min noise exposures (PTS and TTS) (Lomax et al. 2001),
*
Microarray data confirmed by qPCR