Table 2b.
Previously reported genes linked to 110 dB SPL noise exposure
| Symbol | Gene title | Fold-change | P | Reference ID |
|---|---|---|---|---|
| Transcriptional regulators | ||||
| Fosa*,b*,d | FBJ osteosarcoma oncogene | 7.4 | 0.0001 | AV026617 |
| Egr1a*,b* | Early growth response 1 | 5.4 | 0.0001 | NM_007913 |
| Nr4a1b* | Nuclear receptor subfamily 4, group A, member 1 | 4.5 | 0.0000 | NM_010444 |
| Nr4a3b | Nuclear receptor subfamily 4, group A, member 3 | 4.1 | 0.0002 | BE692107 |
| Atf3b* | Activating transcription factor 3 | 4.0 | 0.0000 | BC019946 |
| Cebpbb | CCAAT/enhancer binding protein, beta | 2.4 | 0.0001 | NM_013154 |
| Maffc* | V-maf musculoaponeurotic fibrosarcoma oncogene family, protein F | 2.1 | 0.0000 | BC022952 |
| Junb | Jun oncogene | 2.0 | 0.0024 | NM_010591 |
| Zfp36b | Zinc finger protein 36 | 1.6 | 0.0025 | X14678 |
| Nab2d | Ngf-A binding protein 2 | 1.4 | 0.0255 | NM_008668 |
| Oxidative and inflammatory stress response | ||||
| Dusp1b* | Dual specificity phosphatase 1 | 2.2 | 0.0001 | NM_013642 |
| Dusp5b* | Dual specificity phosphatase 5 | 1.8 | 0.0007 | BB442784 |
| Ptgs2b* | Prostaglandin-endoperoxide synthase 2 | 2.0 | 0.0002 | M94967 |
| Pvrb | Poliovirus receptor | 1.3 | 0.0043 | BB049138 |
| Pvrb | Poliovirus receptor | 1.2 | 0.0076 | NM_009310 |
| Cell cycle/differentiation | ||||
| Btg2a*,b | B-cell translocation gene 2 | 1.9 | 0.0041 | NM_007570 |
| Btg2a*,b | B-cell translocation gene 2 | 1.8 | 0.0131 | NM_007570 |
| Gdf15b* | Growth differentiation factor 15 | 1.4 | 0.0044 | NM_011819 |
a
Prior NIHL study = 90 min noise exposures (PTS and TTS); 2.0-fold-changes; no FDR utilized (Cho et al. 2004),
b
Prior NIHL study = Impulse noise, 2.0-fold-changes (P < 0.008), FDR = 0.25 (Kirkegaard et al. 2006),
c
Salicylate ototoxicity = 2-fold up-regulation, No FDR utilized (Im et al. 2007),
d
Prior NIHL study = 90 min noise exposures (PTS and TTS) (Lomax et al. 2001),
*
Microarray data confirmed by qPCR