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. Author manuscript; available in PMC: 2016 Jul 22.
Published in final edited form as: Sci Transl Med. 2015 Jul 22;7(297):297ra113. doi: 10.1126/scitranslmed.aab1290

Fig. 3. DHED treatment elicits neuroprotection in a rat model of ischemic stroke.

Fig. 3

(A) OVX Sprague-Dawley rats were treated with DHED (0.8 to 100 μg/kg, s.c.) 1 h before tMCAO followed by 24-h reperfusion. The E2-treated group received 200 μg/kg, s.c. TCC-stained brain sections are representative of three animals per indicated treatment and from the same animals within each column. Pale-colored regions indicate areas of infarct whereas red-colored regions representing viable areas. Infarct volumes are charted as averages ± SEM (n = 3 per treatment group). (B) ND scores observed in the experiment described in (A). Data are averages ±SEM (n = 3 per treatment group). (C) Measured initial DHED to E2 conversion rates in major brain areas with tissue harvested 1 h after tMCAO. Data are averages ± SEM (n = 3 per area). (D) Infarct volumes after treatment with 100 μg/kg s.c. DHED 1 h, 2 h and 3 h after tMCAO. Data are averages ± SEM (n = 3 per treatment group). (E) ND scores observed in the experiment described in (D). P values were determined by one-way ANOVA using SNK multiple comparison test.