Fig 3. Power comparison between CCRET and PLINK 1-sided tests for simulation I-A: between-locus heterogeneity of the dosage simulation.

As detailed in section “Simulation Design”, we considered 6 heterogeneity models with different proportions of risk-associated (${\beta }_m^{DS.•}>0$) or protective (${\beta }_m^{DS.•}<0$) effects among causal loci. Black O line: CCRET; Blue Δ: PLINK 1-sided test analyzing deletions and duplications combined; Green +: PLINK 1-sided test analyzing only duplications; Magenta x: PLINK 1-sided test analyzing only deletions.