Table 1. List of differentially-expressed metabolites identified at different stages of infection (infected “I” vs control “C”).
| VIP | m/z | Rt (min) | metabolites | F.C.* | p-value | Metabolic pathways | |
|---|---|---|---|---|---|---|---|
| 7I/7C(+) | 2.897 | 454.2596 | 5.79 | PC(12:0) | 0.58 | 2.56E-02 | Not known |
| 3.370 | 497.2694 | 4.82 | Leukotriene D4 | -1.03 | 5.74E-03 | Arachidonic acid metabolism | |
| 7I/7C(-) | 2.275 | 476.2775 | 11.57 | PE(18:2) | 0.84 | 4.16E-02 | Not known |
| 2.841 | 606.0742 | 1.68 | UDP-N-acetyl-D-galactosamine | 0.73 | 5.10E-03 | Amino sugar and nucleotide sugar metabolism | |
| 2.756 | 267.0733 | 0.85 | Aconitic acid | 0.33 | 7.65E-03 | TCA cycle | |
| 2.389 | 173.0088 | 1.09 | Inosine | -0.25 | 2.98E-02 | Purine metabolism | |
| 14I/14C(+) | 1.363 | 524.3713 | 13.25 | PC(18:0)/ PE(21:0) | 2.11 | 2.72E-02 | Not known |
| 1.809 | 284.0995 | 1.24 | Guanosine | 2.09 | 6.32E-04 | Purine metabolism | |
| 1.415 | 152.0565 | 1.24 | Guanine | 2.03 | 2.02E-02 | Purine metabolism | |
| 1.356 | 218.1388 | 0.95 | Propionyl-L-carnitine | 1.86 | 2.82E-02 | Not known | |
| 1.807 | 137.0457 | 1.26 | Hypoxanthine | 1.8 | 6.46E-04 | Purine metabolism | |
| 1.867 | 269.0888 | 1.26 | Inosine | 1.79 | 2.64E-04 | Purine metabolism | |
| 1.537 | 438.2982 | 12.43 | PE (P–16:0) | 1.54 | 9.16E-03 | Not known | |
| 1.493 | 482.3246 | 13.09 | PC(15:0)/ PE(18:0) | 1.52 | 1.25E-02 | Not known | |
| 1.257 | 204.1231 | 0.87 | Acetylcarnitine | 1.48 | 4.64E-02 | Not known | |
| 1.249 | 303.2323 | 12.57 | Eicosapentaenoic Acid | 1.2 | 4.82E-02 | Biosynthesis of unsaturated fatty acids | |
| 1.555 | 480.3089 | 12.39 | PC(15:1)/ PE(18:1) | 0.98 | 8.03E-03 | Not known | |
| 1.246 | 520.3401 | 11.76 | PC(18:2) | 0.79 | 4.88E-02 | Not known | |
| 1.393 | 518.3222 | 12.22 | PC(18:3) | 0.42 | 2.31E-02 | Not known | |
| 1.315 | 163.9779 | 0.74 | Selenocysteine | -0.3 | 3.49E-02 | Selenocompound metabolism | |
| 1.385 | 302.3059 | 10.64 | Sphinganine | -0.33 | 2.41E-02 | Sphingolipid metabolism | |
| 1.270 | 175.1189 | 0.72 | Arginine | -0.37 | 4.37E-02 | Arginine and proline metabolism | |
| 1.814 | 509.4306 | 5.87 | DG(28:2) | -0.6 | 5.90E-04 | Not known | |
| 1.396 | 214.0116 | 0.91 | 4-Phospho-L-aspartate | -0.62 | 2.27E-02 | Glycine, serine and threonine metabolism | |
| 1.428 | 454.2596 | 5.79 | PC(12:0) | -0.73 | 1.87E-02 | Not known | |
| 1.469 | 426.2259 | 4.73 | PC(10:0) | -0.74 | 1.45E-02 | Not known | |
| 1.299 | 433.233 | 4.70 | PA(18:3) | -0.75 | 3.79E-02 | Not known | |
| 1.262 | 653.3687 | 7.47 | PI(22:2) | -0.81 | 4.53E-02 | Not known | |
| 1.600 | 468.992 | 5.57 | dUTP | -1.14 | 5.63E-03 | Pyrimidine metabolism | |
| 1.633 | 422.2641 | 7.59 | N-acetylsphingosine 1-phosphate | -1.2 | 4.25E-03 | Not known | |
| 1.588 | 129.0659 | 1.37 | L-γ-Cyano-γ-aminobutyric acid | -1.28 | 6.21E-03 | Not known | |
| 1.523 | 104.0714 | 1.37 | γ-Aminobutyric acid | -1.38 | 1.01E-02 | Not known | |
| 1.397 | 244.0932 | 1.46 | Cytidine | -1.47 | 2.26E-02 | Pyrimidine metabolism | |
| 1.677 | 142.0264 | 1.33 | O-Phosphorylethanolamine | -1.47 | 2.86E-03 | Glycerophospholipid and sphingolipid metabolism | |
| 1.625 | 597.5586 | 7.76 | DG(34:0) | -1.78 | 4.57E-03 | Not known | |
| 1.707 | 184.0735 | 1.37 | Phosphocholine | -1.8 | 2.12E-03 | Glycerophospholipid metabolism | |
| 1.790 | 134.0449 | 1.38 | L-Aspartic Acid | -1.91 | 8.10E-04 | Alanine, aspartate and glutamate metabolism | |
| 1.852 | 126.022 | 1.39 | Taurine | -2 | 3.35E-04 | Primary bile acid biosynthesis; Taurine and hypotaurine metabolism | |
| 14I/14C(-) | 1.458 | 436.2827 | 12.10 | PE(P–16:0/0:0) | 1.23 | 2.85E-02 | Not known |
| 1.711 | 327.2325 | 14.66 | Docosahexaenoic acid | 1.06 | 6.13E-03 | Biosynthesis of unsaturated fatty acids | |
| 1.522 | 452.2777 | 11.85 | PC(13:0)/ PE(16:0) | 1.01 | 2.04E-02 | Not known | |
| 1.387 | 480.3088 | 12.71 | PC(15:0)/ PE(18:0) | 1 | 4.00E-02 | Not known | |
| 1.453 | 528.3086 | 12.09 | PE(22:4) | 0.66 | 2.91E-02 | Not known | |
| 1.543 | 303.2326 | 14.83 | Arachidonic Acid | 0.6 | 1.82E-02 | Arachidonic acid metabolism | |
| 1.365 | 500.2778 | 11.59 | PE(20:4) | 0.6 | 4.40E-02 | Not known | |
| 1.622 | 175.0251 | 1.94 | Ascorbic acid | 0.47 | 1.13E-02 | Ascorbate and aldarate metabolism | |
| 1.467 | 203.0822 | 3.17 | Tryptophan | 0.35 | 2.73E-02 | Tryptophan metabolism | |
| 1.421 | 131.0381 | 0.60 | Glutaric acid | -0.33 | 3.41E-02 | Fatty acid metabolism | |
| 1.697 | 165.0405 | 14.40 | Ribonic acid | -1.45 | 6.81E-03 | Not konwn | |
| 21I/21C(+) | 2.282 | 308.0909 | 0.92 | Glutathione | 1.84 | 8.35E-03 | Cysteine and methionine metabolism |
| 2.019 | 258.1104 | 0.87 | Glycerophosphocholine | 1.35 | 2.83E-02 | Not known | |
| 21I/21C(-) | 1.631 | 214.0467 | 0.64 | Glycerylphosphorylethanolamine | 0.74 | 4.57E-02 | Not known |
| 2.152 | 323.0298 | 0.70 | Uridine monophosphate | 0.73 | 2.01E-03 | Not known | |
| 1.751 | 243.0616 | 0.86 | Uridine | 0.71 | 2.76E-02 | Pyrimidine metabolism | |
| 1.964 | 149.0452 | 0.68 | Ribose | 0.4 | 8.80E-03 | Carbon metabolism | |
| 1.650 | 346.0557 | 0.72 | dGMP | 0.31 | 4.24E-02 | Purine metabolism | |
| 1.912 | 146.0459 | 0.67 | Glutamate | 0.24 | 1.21E-02 | Alanine, aspartate and glutamate metabolism | |
| 2.043 | 179.0552 | 0.64 | α-D-Glucose | 0.22 | 5.09E-03 | Not known | |
| 1.675 | 102.0559 | 0.67 | γ-Aminobutryic acid | 0.2 | 3.83E-02 | Not known | |
| 1.715 | 154.0618 | 0.61 | Histidine | -0.21 | 3.23E-02 | Histidine metabolism | |
| 1.746 | 191.0198 | 0.81 | Citric acid | -0.4 | 2.83E-02 | TCA cycle | |
| 1.663 | 500.2778 | 11.59 | PE(20:4) | -0.44 | 4.02E-02 | Not known | |
| 2.017 | 128.0355 | 0.85 | Pyroglutamic acid | -0.54 | 6.16E-03 | Glutathione metabolism | |
| 1.733 | 478.2933 | 12.08 | PC(15:1)/ PE(18:1) | -0.62 | 3.00E-02 | Not known | |
| 1.654 | 452.2777 | 11.85 | PC(13:0)/ PE(16:0) | -0.73 | 4.17E-02 | Not known | |
| 1.785 | 480.3088 | 12.71 | PC(15:0)/ PE(18:0) | -0.78 | 2.36E-02 | Not known | |
| 1.774 | 218.103 | 2.18 | Pantothenic Acid | -0.81 | 2.49E-02 | beta-Alanine metabolism; Pantothenate and CoA biosynthesis | |
| 1.641 | 436.2827 | 12.10 | PE(P–16:0/0:0) | -0.89 | 4.38E-02 | Not known | |
| 1.904 | 476.2775 | 11.57 | PE(18:2) | -1.19 | 1.27E-02 | Not known |
* indicates log2 fold change
+ indicates ESI+ mode
- indicates ESI- mode