Fig 1. Alteration of biofilm formation by different reaction inhibitions in the histidine and purine synthesis pathways.

Reactions indicated with magenta and cyan arrows were experimentally identified by Musken et al. [22]. We predicted reactions indicated with red and green arrows. Abbreviations: aicar, 5-phosphoribosyl-4-carbamoyl-5-aminoimidazole; prpp, 5-phosphoribosyl diphosphate; amp, adenylate. See S1 Supporting Information for the definition of the remaining of the abbreviations.