Fig 4. Dysregulation of secondary metabolites related to biofilm formation by inhibition of anthranilate degradation.

(A) Sketch of the metabolic pathways involved in anthranilate and chorismate metabolism. Metabolite names written in red were predicted to increase when the reactions marked with a red x, which correspond to the low biofilm producers identified by Costaglioli et al. [11], were inhibited. (B) Correlation of the gene expression intensity of genes associated with anthranilate- and chorismate-derived secondary metabolites, psl and pel genes, with the genes of the kynurenine pathway.