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. 2015 Sep 15;8:2555–2563. doi: 10.2147/OTT.S86899

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© 2015 Chen et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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The distribution of the inducible ClyA gene expression.

Notes: (A) Bioluminescence images were obtained following IV injection of the engineered Salmonella typhimurium before doxycycline administration. Expression of luxCDABE in the advanced gliomas was verified by the in vivo bioluminescence imaging at 1, 2, and 3 days after IV injection of the engineered S. typhimurium. (B) Immunoblotting analysis of the expression of ClyA in tumor tissues from rats injected with engineered S. typhimurium before (−) and after doxycycline induction (+). (C) The observed body weights of rats were not significantly different between the three groups at the first 7 days of treatment. P>0.05.

Abbreviations: ClyA, cytolysin A; IV, intravenous; Dox, doxycycline; PBS, phosphate-buffered saline; SL, treatment group; d, days.