Table 1.
Physicochemical properties of selected natural compoundsa
| Natural compound | Partition coefficient (logP) | Polar surface area/molecular surface area (Å2) |
|---|---|---|
| Apigenin | 2.71 | 86.99/326.60 |
| Baicalein | 2.71 | 86.99/325.74 |
| Berberine | −1.28 | 40.8/473.39 |
| Caffeic acid | 1.53 | 77.76/226.17 |
| Caffeine | −0.55 | 58.44/269.15 |
| Catechin | 1.80 | 110.38/373.00 |
| Cinnamaldehyde | 1.98 | 17.07/194.07 |
| Curcumin | 4.12, 3.29b | 93.06/509.73 |
| Epigalloctechin gallate | 3.08 | 197.37/556.67 |
| Ellagic acid | 2.32 | 133.52/319.89 |
| Epicatechin | 1.80 | 110.38/373.01 |
| Eugenol | 2.61 | 29.46/257.78 |
| Gambogic acid | 7.78 | 119.36/906.97 |
| Genistein | 3.08, 3.04c | 86.99/325.45 |
| 6-Gingerol | 3.62 | 66.76/507.44 |
| Hydroxytyrosol | 0.89 | 60.69/230.61 |
| Kaempferol | 2.46, 3.11c | 107.22/337.38 |
| Luteolin | 2.40 | 107.22/337.39 |
| Morin | 2.16 | 127.45/348.34 |
| Naringenin | 2.84, 2.6c | 86.99/351.06 |
| Oleuropein | 0.11 | 201.67/727.25 |
| Paeonol | 1.72 | 46.53/251.92 |
| Quercetin | 2.16, 1.82c | 127.45/348.11 |
| Resveratrol | 3.40 | 60.69/308.38 |
| Rosmarinic acid | 3.00 | 144.52/456.21 |
| Salidroside | −0.58 | 119.61/426.44 |
| Salvianolic acid B | pH dependentd | N/A |
| Silibinin | 2.63 | 155.14/614.71 |
| Tanshinone I | 4.00 | 47.28/368.83 |
| Taxifolin | 1.82 | 127.45/367.80 |
| Thymoquinone | 2.55 | 34.14/245.97 |
| Tyrosol | 1.19 | 40.46/219.74 |
| Ursolic acid | 6.58 | 57.53/795.27 |
Notes:
a
LogP and surface area values are obtained from source http://www.chemicalize.org unless specified
b
Data from Grynkiewicz G, Ślifirski P. Curcumin and curcuminoids in quest for medicinal status. Acta Biochim Pol. 2012;59(2):201–212.28
c
Data from Rothwell JA, Day AJ, Morgan MR. Experimental determination of octanol-water partition coefficients of quercetin and related flavonoids. J Agric Food Chem. 2005;53(11):4355–4360.29
d
Data from Li J, Liu P, Liu JP, et al. Bioavailability and foam cells permeability enhancement of Salvianolic acid B pellets based on drug-phospholipids complex technique. Eur J Pharm Biopharm. 2013;83(1):76–86.30
Abbreviation: N/A, not available.