Table 3.
Serum neutralizing antibody titers of AG129 mice immunized with 105 pfu of DENVax-1, DENVax-2, DENVax-3 or DENVax-4 compared to PBS treated mice. Titers determined for pool sera obtained at days 40 and 56 after primary vaccination.
| Group | Neutralizing antibody titers (PRNT50)
|
|||||||
|---|---|---|---|---|---|---|---|---|
| DEN-1
|
DEN-2
|
DEN-3
|
DEN-4
|
|||||
| D40 | D56 | D40 | D56 | D40 | D56 | D40 | D56 | |
| PBS | 1 | 1 | 1 | 1 | 11 | 30 | 1 | 1 |
| DENVax-1 | 1920 | 5120 | 21 | 20 | 120 | 480 | 11 | 30 |
| DENVax-2 | 30 | 40 | 1280 | 1280 | 320 | 320 | 20 | 20 |
| DENVax-3 | 21 | 80 | 1 | 20 | 1280 | 1920 | 30 | 40 |
| DENVax-4 | 1 | 1 | 50 | 20 | 120 | 480 | 200 | 480 |