Table 1.
Clinical |
Acute cyanosis |
"Gasping" (terminal respiratory pattern in which breathing is laborious and audible) |
Respiratory rate > 40 or < 6 breaths per minute |
Shock (persistent severe hypotension, defined as SBP < 90mmHg for ≥ 60 minutes with a pulse of at least 120 beats per minute, despite liquid infusion [> 2L]) |
Oliguria unresponsive to fluids or diuretics (urine output < 30mL/hour for 4 hours or < 400mL/24 hours) |
Coagulation disorders (coagulation failure as assessed by a clotting assay or by the absence of coagulation after 7 to 10 minutes) |
Loss of consciousness for 12 hours or more (defined as a score < 10 on the Glasgow Coma Scale) |
Loss of consciousness and absence of a pulse or heartbeat |
Stroke (neurological deficit of cerebrovascular cause that persists for more than 24 hours) |
Uncontrolled convulsion |
Jaundice in the presence of pre-eclampsia (pre-eclampsia is defined as the presence of hypertension associated with proteinuria. Hypertension is defined as SBP ≥ 140mmHg and/or DBP ≥ 90mmHg on at least two occasions, with an interval of 4 to 6 hours after the 20th week of pregnancy. Proteinuria is defined as excretion of 300mg or more protein in 24 hours, or ≥ 1 + proteinuria in at least two measurements with an interval of 4 to 6 hours) |
Laboratory |
SO2 < 90% for 60 minutes or more |
PaO2/FiO2 < 200mmHg |
Creatinine ≥ 300/µmol/L or ≥ 3.5mg/dL |
Bilirubin ≥ 100µmol/L or ≥ 6.0mg/dL |
pH < 7.1 |
Lactate > 5 |
Acute thrombocytopenia (< 50,000) |
Loss of consciousness and presence of glucose and ketone in the urine |
Treatment |
Use of vasoactive drugs |
Hysterectomy due to infection or hemorrhage |
Transfusion ≥ 5 red blood cell units |
Intubation and ventilation for ≥ 60 minutes unrelated to anesthesia |
Dialysis for acute renal failure |
Cardiorespiratory arrest |
SBP - systolic blood pressure; DBP - diastolic blood pressure; SO2 - oxygen saturation; PaO2/FiO2 - arterial oxygen partial pressure/fraction of inspired oxygen.