Table 1.
Characteristics of 66 NSCLC patients presenting with 1-4 synchronous brain metastases as their only site of disease.
| Characteristic | N | % | |
|---|---|---|---|
| Age (years) | (Median 57, Range 35-90) | ||
| >60 years | 25 | 36% | |
| ≤60 years | 41 | 64% | |
| Sex | |||
| Male | 24 | 36% | |
| Female | 42 | 64% | |
| Histology | |||
| Adenocarcinoma | 38 | 58% | |
| Squamous cell carcinoma | 9 | 14% | |
| NSCLC NOS | 19 | 29% | |
| KPS* | |||
| 100 | 12 | 18% | |
| 80-90 | 31 | 47% | |
| 70 | 13 | 20% | |
| Thoracic stage | |||
| IA | 3 | 5% | |
| IB | 6 | 9% | |
| IIA | 7 | 11% | |
| IIB | 3 | 5% | |
| IIIA | 34 | 51% | |
| IIIB | 13 | 20% | |
| Number of brain metastases | |||
| 1 | 33 | 50% | |
| 2 | 22 | 33% | |
| 3 | 10 | 15% | |
| 4 | 1 | 2% | |
| Size of largest brain metastasis (cm) | (Median 1.8, Range 0.1-6.1) | ||
| ≤ 3 cm | 55 | 83% | |
| > 3 cm | 10 | 15% | |
| Unknown | 1 | 2% | |
| Initial CNS therapy | |||
| WBRT + SRS + Surgery | 3 | 5% | |
| WBRT + SRS | 11 | 17% | |
| WBRT + Surgery | 21 | 32% | |
| WBRT only | 7 | 11% | |
| SRS + Surgery | 4 | 6% | |
| SRS only | 18 | 27% | |
| None | 2 | 3% | |
| Initial thoracic therapy | |||
| Surgery + RT | 5 | 8% | |
| Surgery only | 14 | 21% | |
| RT > 45 Gy + chemotherapy | 19 | 29% | |
| RT ≤ 45 Gy +/− chemotherapy | 8 | 12% | |
| Chemotherapy alone | 17 | 26% | |
| Supportive care alone | 3 | 5% |
NSCLC: Non-small cell lung cancer; NOS: not otherwise specified; KPS: Karnofsky performance status; CNS: central nervous system; WBRT: whole brain radiotherapy; SRS: stereotactic radiosurgery; RT: radiation therapy.
*
Totals do not add up due to missing data.