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. 2015 Oct 2;10(10):e0138443. doi: 10.1371/journal.pone.0138443

Table 3. Comparison of adipokines and their receptors (AdipoR1, AdipoR2 and Ob-R), COXs, F2-isoprostanes, prostaglandin F, α-SMA and aromatase in breast tissues adjacent to the tumor and tumor tissues of breast cancer patients based on a score calculated from the staining intensity and percent of area immunostained tissues.

Breast tumor tissues Adjacent breast tissues to tumor
Biomarkers n Score n Score Paired T test p<0.05
AdipoR1 27 0.93±0.27 25 1.24±0.36 0.027
AdipoR2 30 0.83±0.28 29 0.83±0.34 ns
Adiponectin 29 0.90±0.19 25 1.15±0.46 0.0023
Ob-R 30 1.00±0.00 28 1.21±1.34 0.01
Leptin 30 1.07±0.12 27 1.26±0.38 0.027
COX-1 28 1.18±0.29 26 1.38±0.47 ns
COX-2 27 0.70±0.42 24 0.95±0.09 0.016
F2-isoprostanes 29 0.48±0.50 25 0.64±0.51 0.026
PGF 29 0.55±0.49 26 0.73±0.39 0.05
α-SMA 30 0.79±0.55 27 1.19±0.42 0.027
Aromatase 26 1.04±0.22 26 0.96±0.07 ns

Results are the mean ± SEM; ns = not significant; Adipo R1/R2 = adiponectin receptor; Ob-R = leptin receptor; COX = cyclooxygenase; PGF = prostaglandin F; α-SMA = α-Smooth Muscle Actin