Table 3. Comparison of adipokines and their receptors (AdipoR1, AdipoR2 and Ob-R), COXs, F2-isoprostanes, prostaglandin F2α, α-SMA and aromatase in breast tissues adjacent to the tumor and tumor tissues of breast cancer patients based on a score calculated from the staining intensity and percent of area immunostained tissues.
| Breast tumor tissues | Adjacent breast tissues to tumor | ||||
|---|---|---|---|---|---|
| Biomarkers | n | Score | n | Score | Paired T test p<0.05 |
| AdipoR1 | 27 | 0.93±0.27 | 25 | 1.24±0.36 | 0.027 |
| AdipoR2 | 30 | 0.83±0.28 | 29 | 0.83±0.34 | ns |
| Adiponectin | 29 | 0.90±0.19 | 25 | 1.15±0.46 | 0.0023 |
| Ob-R | 30 | 1.00±0.00 | 28 | 1.21±1.34 | 0.01 |
| Leptin | 30 | 1.07±0.12 | 27 | 1.26±0.38 | 0.027 |
| COX-1 | 28 | 1.18±0.29 | 26 | 1.38±0.47 | ns |
| COX-2 | 27 | 0.70±0.42 | 24 | 0.95±0.09 | 0.016 |
| F2-isoprostanes | 29 | 0.48±0.50 | 25 | 0.64±0.51 | 0.026 |
| PGF2α | 29 | 0.55±0.49 | 26 | 0.73±0.39 | 0.05 |
| α-SMA | 30 | 0.79±0.55 | 27 | 1.19±0.42 | 0.027 |
| Aromatase | 26 | 1.04±0.22 | 26 | 0.96±0.07 | ns |
Results are the mean ± SEM; ns = not significant; Adipo R1/R2 = adiponectin receptor; Ob-R = leptin receptor; COX = cyclooxygenase; PGF2α = prostaglandin F2α; α-SMA = α-Smooth Muscle Actin