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. 2015 Oct 2;10(10):e0138443. doi: 10.1371/journal.pone.0138443

Table 5. Comparison of adipokines and their receptors (AdipoR1, AdipoR2 and Ob-R), COXs, F2-isoprostanes and prostaglandin F, α-SMA and aromatase in the breast tissues adjacent to the tumor and tumor tissues of breast cancer patients on the basis of staining intensity.

Breast Tumor tissues Adjacent breast Tissue to tumor
Biomarkers n Intensity (AU) n Intensity (AU) Paired T test p<0.05
AdipoR1 27 1.30±0.63 25 1.37±0.47 ns
AdipoR2 30 1.27±0.64 29 0.86±0.36 0.022
Adiponectin 29 1.14±0.42 25 1.50±0.55 0.0023
Ob-R 30 1.57±0.49 28 1.46±0.50 ns
Leptin 30 1.80±0.32 27 1.33±0.44 0.00005
COX-1 28 1.86±0.24 26 1.69±0.43 ns
COX-2 27 0.63±0.51 24 0.33±0.44 0.009
F2-isoprostanes 29 0.59±0.61 25 0.76±0.61 0.025
PGF 29 0.72±0.65 26 1.04±1.59 0.037
α-SMA 30 1.17±0.86 27 1.67±0.49 0.02
Aromatase 26 1.50±0.58 26 1.32±0.48 ns

Results are the mean ± SEM; ns: not significant. AU = Arbitrary Unit; Adipo R1/R2 = adiponectin receptor; Ob-R = leptin receptor; COX = cyclooxygenase; PGF = prostaglandin F; α-SMA = α-Smooth Muscle Actin