Table 2. Prevalence of antibodies to HSV–1 and HSV–2 at enrollment, WIHS 1994–95 cohort, by race and IFNL4 genotype (N = 1,431).
African Americans | |||||||
IFNL4-ΔG/TT Genotype | Total | HSV–1 Positive | p-value | HSV–2 Positive | p-value | HSV–1 or HSV–2 Positive | p-value |
N (%) | N (%) | ||||||
Overall | 1108 | 857 (77.3) | 930 (83.9) | - | 1079 (97.4) | ||
TT/TT | 168 | 124 (73.8) | 137 (81.5) | 163 (97.0) | |||
ΔG/TT | 505 | 393 (77.8) | 418 (82.8) | 488 (96.6) | |||
ΔG/ΔG | 435 | 340 (78.2) | 375 (86.2) | 428 (98.4) | |||
ΔG/ΔG+ΔG/TT | 940 | 733 (78.0) | 0.23 | 793 (84.4) | 0.36 | 916 (97.4) | 0.75 |
European Americans | |||||||
IFNL4-ΔG/TT Genotype | Total | HSV–1 Positive | p-value | HSV–2 Positive | p-value | HSV–1 or HSV–2 Positive | p-value |
N (%) | N (%) | N (%) | |||||
Overall | 323 | 185 (57.3) | 201 (62.2) | - | 273 (84.5) | ||
TT/TT | 134 | 73 (54.5) | 90 (67.2) | 116 (86.6) | |||
ΔG/TT | 151 | 87 (57.6) | 86 (57.0) | 121 (80.1) | |||
ΔG/ΔG | 38 | 25 (65.8) | 25 (65.8) | 36 (94.7) | |||
ΔG/ΔG+ΔG/TT | 189 | 112 (59.3) | 0.39 | 111 (58.7) | 0.12 | 157 (83.1) | 0.39 |