Table 7. Drug sensitivity and drug resistance in different drug groups of patients with community-acquired compared to nosocomial-acquired pneumonia caused by multidrug-resistant Pseudomonas aeruginosa.
MDR Pseudomonas CAP (n = 27), NAP (n = 14) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Drug groups | Active substance | No. of tests of antibiotics on antibiogram | Sensitive | Intermediate | Resistant | ComparisonCAP + NAP | ||||
CAP | NAP | CAP (%) | NAP (%) | CAP(%) | NAP (%) | CAP (%) | NAP (%) | P value | ||
Penicillin | Piperacillin | 27 | 14 | 15 (55.6) | 6 (35.3) | 0 | 0 | 12 (44.4) | 8 (57.1) | 0.741 |
Penicillin + β-lactamase inhibitors | Piperacillin + Tazobactam | 27 | 14 | 15 (55.6) | 7 (50.0) | 0 | 0 | 12 (44.4) | 7 (50.0) | 0.947 |
Cephalosporins | Cefepime | 27 | 14 | 20 (74.1) | 7 (50.0) | 0 | 0 | 7 (25.9) | 7 (50.0) | 0.304 |
Ceftazidime | 27 | 13 | 16 (59.3) | 5 (38.5) | 2 (7.4) | 0 | 9 (33.3) | 8 (61.5) | 0.189 | |
Carbapenems | Imipenem | 27 | 14 | 11 (40.7) | 7 (50.0) | 1 (3.7) | 0 | 15 (55.6) | 7 (50.0) | 0.687 |
Meropenem | 26 | 14 | 12 (46.2) | 6 (42.9) | 3 (11.5) | 1 (7.1) | 11 (42.3) | 7 (50.0) | 0.852 | |
Gyrase inhibitors | Ciprofloxacin | 27 | 13 | 8 (29.6) | 4 (30.8) | 0 | 1 (7.7) | 19 (70.4) | 8 (61.5) | 0.336 |
Levofloxacin | 27 | 14 | 6 (22.2) | 3 (21.4) | 3 (11.1) | 2 (14.3) | 18 (66.7) | 9 (64.3) | 0.956 | |
Aminoglycosides | Gentamicin | 27 | 14 | 15 (55.6) | 10 (71.4) | 0 | 1 (7.1) | 12 (44.4) | 3 (21.4) | 0.162 |
Tobramycin | 25 | 12 | 11 (44.0) | 9 (75.0) | 1 (4.0) | 0 | 13 (52.0) | 3 (27.3) | 0.193 | |
Amikacin | 22 | 11 | 14 (63.6) | 10 (90.9) | 2 (9.1) | 0 | 6 (27.3) | 1 (9.1) | 0.236 | |
Epoxide | Fosfomycin | 7 | 7 | 2 (28.6) | 1 (14.3) | 5 (71.4) | 0 | 0 | 6 (85.7) | 0.0035 |
Polymyxin | Colistin | 4 | 2 | 4 (100) | 2 (100) | 0 | 0 | 0 | 0 | 1.0 |