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. 2015 Oct 2;10(10):e0139238. doi: 10.1371/journal.pone.0139238

Fig 12. Cytotoxicity of pyrimidinedione on HMEECs.

Fig 12

The cytotoxicity of pyrimidinedione was tested on the HMEEC line using a CCK-8 kit. The absorbance of the reaction was measured at 450 nm, and was compared among HMEECs exposed to pyrimidinedione (1 μM, or 5 μM, or 10 μM), 2% Triton X-100 (complete lysis), control (medium alone), and DMSO-control. No significant difference in mean absorbance was detected for HMEECs treated with various concentrations of pyrimidinedione versus untreated or DMSO controls (p> 0.43). However, all were significantly different from triton X-100-treated cells (p< 0.002), indicating no acute cellular cytotoxicity at the tested concentrations. The results were compared by Student’s t-test (*** corresponds to p< 0.002, #corresponds to p>0.43). The error bars represent the SD.