Fig 2. Assessment of in vitro markers of proliferation after citalopram treatment.
A. MTS functional assay results from MC3T3 cells treated with serial dilutions of citalopram (10−4 mol through 10−10 mol). Significant time and dose effects are noted. B. Gene expression markers of proliferation from MC3T3 cells treated with media only or media supplemented with 10−4 mol citalopram. All three markers indicate a biological change due to treatment by 7 days. Jun was found to have significantly greater expression due to treatment at both 3 and 7 days.