Table 2. Associations between SNPs and prostate cancer risk (high versus low risk) in men with PSA3-10ng/mL.
| N (high vs low risk) | Effect of X allele a | ||||||
|---|---|---|---|---|---|---|---|
| SNP | Alleles (O/X) | OO | OX | XX | OR | (95% CI) | p-value |
| 4 PSA-SNPs | |||||||
| rs10788160 | G/A | 107/391 | 68/249 | 9/44 | 0.93 | (0.70, 1.22) | 0.59 |
| rs11067228 | G/A | 25/131 | 95/332 | 64/221 | 1.21 | (0.95, 1.55) | 0.12 |
| rs17632542 | C/T | ./. | 29/75 | 155/609 | 0.62 | (0.38, 1.00) | 0.05 |
| rs2736098 | C/T | 80/280 | 91/350 | 13/54 | 0.93 | (0.70, 1.22) | 0.59 |
| 10 Aggressive Prostate Cancer SNPs | |||||||
| rs10749408 | C/T | 79/324 | 86/278 | 19/82 | 1.03 | (0.81, 1.32) | 0.79 |
| rs10788165 | G/T | 83/293 | 88/312 | 13/79 | 0.85 | (0.66, 1.10) | 0.21 |
| rs11199874 | A/G | 106/391 | 69/249 | 9/44 | 0.94 | (0.71, 1.24) | 0.67 |
| rs11672691 | A/G | 109/408 | 65/241 | 10/35 | 1.05 | (0.79, 1.39) | 0.76 |
| rs11704416 | C/G | 107/446 | 69/211 | 8/27 | 1.25 | (0.94, 1.67) | 0.13 |
| rs1571801 | T/G | 13/51 | 75/294 | 96/339 | 1.08 | (0.83, 1.41) | 0.58 |
| rs1994198 | C/T | 53/230 | 86/320 | 45/134 | 1.23 | (0.97, 1.54) | 0.08 |
| rs4054823 | C/T | 63/224 | 86/321 | 35/139 | 0.93 | (0.73, 1.18) | 0.54 |
| rs4775302 | G/A | 49/138 | 85/339 | 50/207 | 0.82 | (0.65, 1.04) | 0.1 |
| rs6497287 | C/T | 158/578 | 25/101 | 1/5 | 0.9 | (0.58, 1.40) | 0.64 |
OR = odds ratio; CI = confidence interval; p = p-value. The X allele would be expected to be associated with increased risk.
a High vs low risk models are calculated using regression, adjusting for exact age, study centre and 10 principal components to account for confounding by population stratification. Additive model.