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. Author manuscript; available in PMC: 2015 Oct 2.
Published in final edited form as: Expert Opin Drug Discov. 2015 Apr 30;10(7):703–711. doi: 10.1517/17460441.2015.1041913

Figure 1.

Figure 1

Gantt chart showing the onset and progression of synaptic impairment, memory loss and Aβ and tau pathology in 3 mouse Tg models of AD (single APP Tg2576, double APP/PS1, triple 3xTg) and in a physiological model of aging.