Table 1.

Important molecules involved in monocyte trafficking across the vessel wall

Class	Common name	Immunological name	Gene name (mouse)	Function	Main ligands	Expressed on	Number of clinical trials	Of which open	References
Integrins	LFA-1	CD11a, CD18	Itgal, Itgb2	Patrolling, locomotion, arrest	ICAM-1, -2	Monocytes	39	8	8–10
	Mac-1	CD11b, CD18	Itgam, Itgb2	Arrest, locomotion, transmigration, activation	Multiple	Monocytes	575	180	10
	VLA-4	CD 49d, CD29	Itga4, Itgb1	Adhesion, transmigration	VCAM-1	Monocytes	9	4	10
Immunoglobulin superfamily	ICAM-1	CD54	Icam1	Adhesion, transmigration	LFA-1	EC	119	25	10
	ICAM-2	CD102	Icam2	Adhesion, transmigration	LFA-1	EC	81	13
	MCAM	CD146	Mcam	Transmigration		EC	38	16	11
	JAM-A		F11r	Transmigration	LFA-1, JAM-A	EC	2	1	9
					JAM-B
	JAM-B	CD322	Jam2	Transmigration	VLA-4	EC	202	2	12
					JAM-C
					Mac-1
	JAM-C		Jam3	Reverse transmigration	CAR	EC	164	20	12,13
	JAML		Amica1	Arrest, transmigration	VLA-4	Monocytes	116	19	14
	VCAM-1	CD106C	Vcam1	Arrest	PECAM-1	EC	93	20	10
	PECAM-1	D31	Pecam1	Transmigration		EC, monocytes	7	2	15
	Poliovirus receptor	CD155C	Pvr	Transmigration	CD96, DNAM-1, TIGIT PILR	EC, monocytes	11	5	16
	MIC2	D99	Cd99	Transmigration		EC, monocytes	115	49	17
	ICD99L2		Cd99l2	Transmigration	?	EC, monocytes	7	0	18
Selectins	E- selectin	CD62E	Sele	Rolling	ESL-1 PSGL-1 CD44	EC	78	21	19
	P- selectin	CD62P	Selp	Rolling, arrest	PSGL-1	EC	72	22	20
	L-selectin	CD62L	Sell	Rolling, signalling	PSGL1, CD34	Monocytes	44	11	21
Chemokine receptors	CCR1	CD191	Ccr1	Arrest	CCL5	Monocytes	249	71	22
	CCR5	CD195	Ccr5	Spreading, arrest, transmigration	CCL5	Monocytes	226	83	23
	CCR2	CD192	Ccr2	Adhesion, transmgration	CCL2, -7, -12	Monocytes	277	97	24
Other	VE- cadherin	CD144	Cdh5	Transmigration		EC	7	3	25
	Eph A1, -2		Epha1	Transmigration	Ephrin-A ligands	Monocytes	8	5	26
	Eph B1–4		Ephb1	Transmigration	Ephrin-B ligands	Monocytes	17	5	26