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. 2015 Jun 2;32(10):2605–2615. doi: 10.1093/molbev/msv135

Fig. 5.

Fig. 5.

X-linked TFs preferentially regulate X-linked target genes. (A) For TFs on either the X chromosome or autosomes, the proportion of downstream target genes on the X chromosome was determined using a Drosophila regulatory network (Marbach et al. 2012). Boxplots show the distribution of these values for the X-chromosome and the autosomes with the median (center line) as well as 25th and 75th percentiles indicated (box upper and lower bounds) and whiskers extending 1.5× the interquartile range. Mann–Whitney U tests were used to compare the X chromosome and autosomes. (B) For target genes on the X chromosome and autosomes, the proportion of upstream TFs encoded by genes on the X chromosome. Boxplots show the distribution of these values for the X-chromosome and the autosomes with the median (center line) as well as 25th and 75th percentiles indicated (box upper and lower bounds) and whiskers extending 1.5× the interquartile range. Mann–Whitney U tests were performed to compare the X chromosome and autosomes (NS indicates not significant, *P ≤ 0.05, **P ≤ 0.001, and ***P ≤ 1 × 10−4).