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. 2015 Jul 3;147(2):446–457. doi: 10.1093/toxsci/kfv141

FIG. 5.

FIG. 5.

A, Inhibition of aromatase activity in MCF7aro cells by selected compounds. AI assays were carried out by incubating cells for 1 h with the androgen substrate and each compound at a single concentration (10 μM). Exemestane (EXE) (100 nM) was used as the positive control. The assay was carried out in triplicate and the data are expressed as the mean ± standard deviation (SD). The names of the chemicals are shown in Table 2. B, Confirmed inhibition of aromatase activity in MCF7aro cells by compounds trovafloxacin mesylate (C1), imazalil sulfate (E1), and Erlotinib (G1). Aromatase inhibition assays were carried out by incubation of cells for 1 h with the androgen substrate and each compound at various concentrations (10 nM–10 μM). Exemestane (100 nM) was used as a positive control. The assay was carried out in triplicate and the data are expressed as the mean ± standard deviation (SD).