Figure 5.
Inhibitory effect of PTH on Hdac mRNA expression in bone is abolished by LRP6 deficiency. Quantitative RT-PCR analysis of Hdac1 (A), Hdac2 (B), Hdac3 (C), Hdac4 (D), Hdac5 (E) mRNA levels in cortical bone extracts from 3-month-old male WT and KO mice treated with vehicle or PTH daily at 80 mg/kg bw, 5 days a week for 4 weeks. Six mice per treatment group were analyzed. *P < 0.05, **P < 0.01.