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Relationship of total WMH volume to five cognitive domains
| Composite score of cognition | Estimate | SE | p value |
|---|---|---|---|
| Perceptual speed | −0.462 | 0.110 | <0.001 |
| Episodic memory | −0.102 | 0.089 | 0.255 |
| Semantic memory | −0.145 | 0.090 | 0.109 |
| Working memory | 0.032 | 0.122 | 0.792 |
| Visuospatial ability | −0.062 | 0.103 | 0.543 |
Estimates are coefficient of log10 (total WMH volume) in linear regression models adjusted for age, sex, and education
