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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Histopathology. 2015 Jun 4;67(6):771–782. doi: 10.1111/his.12707

Figure 3.

Figure 3

Dilated acinar phenotype (A, B, D, E) and Ductal metaplasia (C and F). A. 40× view of H& E of ESMG from a patient with BE with high-grade dysplasia; 88% of the acini were scored as dilated. B. 100× view of same ESMG with H&E illustrating dilated mucinous glands. C. 100× view of ESMG from an EAC patient with 84% ductal metaplastic acini and prominent inflammation. D. 40× view of CK7 staining illustrating contrast between dilated mucinous glands and more densly staining ducts of ESMG shown in panel A. E. 100× view of same ESMG illustrating dilated mucinous glands with CK7 staining; the arrow in panel E indicates normal CK7 pattern in dilated mucinous acini.. F. 100× view of CK7 staining of ductal metaplasia and inflammation within the ESMGs shown in Panel C; the arrow in panel F indicates ductal pattern of prominent cytoplasmic CK7 staining. Both patients had BE with high-grade dysplasia and EAC and both were treatment naive (no radiation or chemotherapy) prior to esophagectomy.