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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Clin Cancer Res. 2015 May 26;21(19):4356–4364. doi: 10.1158/1078-0432.CCR-14-3357

Figure 5. Sensitivity of HNSCC PDXs to BGJ398.

Figure 5

A, The FGFR1 protein expression levels in extracts from a PDX model negative for FGFR1 mRNA and diploid for GCN (CUHN036), a PDX showing high expression of FGFR1 protein and diploid for GCN (CUHN015) and a PDX exhibiting high FGFR1 mRNA and increased GCN (CUHN072) was measured by immunoblot analysis using the C-terminal antibody (Epitomics) with the α-subunit of the NaK-ATPase as a loading control. The effect of daily oral gavage with BGJ398 (30 mg/kg) on flank xenograft growth of CUHN015 (B), and CUHN072 (C) is shown. The experiment was performed as described in the Materials and Methods.