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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Clin Cancer Res. 2015 Jun 12;21(19):4312–4320. doi: 10.1158/1078-0432.CCR-15-0340

Figure 2.

Figure 2

The PC regimen depletes and suppresses host lymphocytes. (a) Absolute lymphocyte count (ALC; left panel) and absolute neutrophil count (ANC; right panel) are shown for each patient before start of the pentostatin plus cyclophosphamide (PC) regimen, and then at six time points performed on a bi-weekly basis over the 21-day treatment interval. The crossbar at each measurement indicates the median value. (b) The absolute number of CD4+ T cell subsets (left panel) and CD8+ T cell subsets (right panel) was determined before and after the 21-day PC regimen (subsets including naïve, central memory [EM], effector memory [EM], and T effector memory expressing CD45RA [TEMRA]; values shown are mean values ± SEM). (c) T cells collected before and after administration of the PC regimen were co-stimulated for 24 hours; the resultant supernatant was tested for cytokine content (results expressed as pg/ml per 1 × 106 cells/ml per 24 hours). (d) Plasma was collected before the PC regimen (day -21) and after the PC regimen (day -3) and tested for IL-7 and IL-15 content by Luminex assay (results in pg/ml).