Table II.
Summary of DLI Therapy |
GVHD |
Tumor Staging |
||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Acute |
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UPN | # DLI |
Specifics | s | g | l | Gr | Late Acute |
Chronic | day +28 |
day +60 |
day +100 |
Overall Outcome |
01 | 3 | T-Rapa Series | 0 | 0 | 0 | 0 | G | N.E. | SD | SD | PD | Death (d 131) RCC |
02 | 4 | T-Rapa Series + Standard DLI (1) | 1 | 0 | 0 | I | None | V-V | SD | SD | PD | Death (d 740) RCC |
03 | 3 | T-Rapa Series | 0 | 0 | 0 | 0 | N.E. | N.E. | SD | PD | PD | Death (d 134) RCC |
04 | 7 | T-Rapa Series + Standard DLI (4) | 0 | 0 | 0 | 0 | S, G, L | None | SD | SD | PD | Death (d 303) Infection, GVHD, RCC |
05 | 5 | T-Rapa Series + Standard DLI (2) | 0 | 0 | 0 | 0 | N.E. | N.E. | SD | SD | PD | Death (d 127) RCC |
06 | 4 | T-Rapa Series + Standard DLI (1) | 0 | 0 | 0 | 0 | S | None | SD | SD | SD | Alive (d +1591) |
07 | 2 | T-Rapa #1, #2 | 0 | 0 | 0 | 0 | S | N.E. | SD | PD | PD | Death (d 165) RCC |
08 | 5 | T-Rapa Series + Standard DLI (2) | 0 | 0 | 0 | 0 | None | None | SD | SD | PD | Death (d 300) RCC |
09 | 4 | T-Rapa Series + Standard DLI (1) | 0 | 0 | 0 | 0 | N.E. | N.E. | SD | PD | PD | Death (d 143) RCC |
10 | 1 | T-Rapa #1 | 2 | 0 | 0 | I | N.E. | N.E. | SD | PD | NA | Death (d 78) RCC |
Abbreviations: T-Rapa Series, indicates patient received T-Rapa cells at day 0 of transplant and at days 14 and 45 post-transplant; Standard DLI, indicates donor lymphocyte infusion consisting of unmanipulated donor T cells; N.E., not evaluable; N.A., not applicable; S, G, L indicates skin, gut, or liver acute GVHD; V-V, indicates vulvar vaginal chronic GVHD; SD, indicates stable disease; PD, indicates progressive disease; RCC, indicates disease active at time of death (SD or PD).
Patients UPN07 and UPN10 did not receive all T-Rapa infusions due to poor performance status.