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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Cancer Res. 2015 Sep 17;75(19):4012–4015. doi: 10.1158/0008-5472.CAN-15-1216

Figure 1. Facilitated recruitment of MYC to chromatin by interaction with WDR5.

Figure 1

The cartoon represents two different genes in two different cell types. Both genes carry E-box consensus sites for binding MYC/MAX dimers. In Cell Type A, Gene A has recently been transcribed, and is marked by the presence of both H3K4 methylation (“Me”) and WDR5, which exists as part of a multi-protein complex (gray ovals). Because stable chromatin recognition by MYC depends on both DNA and WDR5 interactions, MYC associates with Gene A, and not Gene B, in this cell. In Cell Type B, the situation is reversed and only Gene B can recruit MYC.