Table 1.
Distribution of study subjects of the Harvard Lung Cancer Study, the CARET study, the Texas Lung Study, and the ICARE study by demographic and risk factors
| Harvard Lung Cancer Study |
CARETa |
Texas Lung Study |
ICAREb |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variable | Case (n=833) |
Control (n=739) |
p-value | Case (n=394) |
Control (n=390) |
p-value | Case (n=1154) |
Control (n=1137) |
p-value | Case (n=1412) |
Control (n=1119) |
p-value |
| Age (years)c | 65.5 (10.2) | 59.3 (11.5) | <0.0001 | 70.3 (5.3) | 71.6 (5.3) | 0.03 | 62.1 (10.8) | 62.1 (8.9) | 0.013 | 59.6 (9.3) | 58.1 (9.8) | 0.0002 |
| Sex | 0.01 | 0.86 | 0.87 | <0.0001 | ||||||||
| Male (%) | 396 (47.5) | 397 (53.7) | 252 (64.0) | 247 (63.3) | 658 (57.0) | 644 (56.6) | 1183 (83.8) | 1011 (90.3) | ||||
| Female (%) | 437 (52.5) | 342 (46.3) | 142 (36.0) | 143 (36.7) | 496 (43.0) | 493 (43.4) | 229 (18.2) | 108 (9.7) | ||||
| Smoking | <0.0001 | 0.62 | 0.01 | <0.0001 | ||||||||
| Current smokingd | 366 (43.9) | 232 (31.4) | 306 (77.7) | 297 (76.2) | 550 (47.7) | 481 (42.3) | 628 (44.5) | 278 (24.8) | ||||
| Pack-yearsc | 55 (33.9) | 29.7 (26.5) | <0.0001 | 53.1 (21.5) | 52.0 (22.5) | 0.85 | 51.5 (31.4) | 44.6 (30.2) | 38.9 (23) | 18.9 (17.2) | <0.0001 | |
| Asbestos Exposure | 0.049 | 0.73 | 0.002 | 0.0019 | ||||||||
| Never | 650 (78.0) | 606 (82.0) | 333 (84.5) | 333 (85.4) | 990 (86.2) | 1031 (90.8) | 536 (38.0) | 493 (44.1) | ||||
| Ever | 183 (22.0) | 133 (18.0) | 61 (15.5) | 57 (14.6) | 159 (13.8) | 105 (9.2) | 876 (62.0) | 626 (55.9) | ||||
| Asbestos Exposure | ||||||||||||
| Scorece | 0.6 (1.4) | 0.5 (1.2) | 0.016 | 0.5 (1.1) | 0.4 (1.0) | 0.3 | NA | NA | 0.7 (1.1) | 0.5 (0.9) | <0.0001 | |
| Histology | ||||||||||||
| Adenocarcinoma | 406 (48.7) | 105 (26.7) | 597 (51.7) | 536 (38.0) | ||||||||
| Squamous | 192 (23.1) | 70 (17.8) | 309 (26.8) | 452 (32.0) | ||||||||
| Small cell carcinoma | 85 (10.2) | 52 (13.2) | 0 (0.0) | 208 (14.7) | ||||||||
| Other | 150 (18.0) | 167 (42.3) | 248 (21.5) | 216 (15.3) | ||||||||
a
CARET, Beta-Carotene and Retinol Efficacy Trial
b
ICARE, Investigation of occupational and environmental CAuses of REspiratory cancers
c
Mean(SD)
d
Current or quit within the last year
e
log-transformed