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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2015 Jul 21;24(10):1564–1573. doi: 10.1158/1055-9965.EPI-15-0021

Table 2.

Top associated findings of asbestos-gene interaction terms determined by likelihood-ratio tests (LRT) replicated in in silico

SNP Cytogenetic
region		 Gene MAF1 Regression
coefficient1 		P-value1 MAF2 Regression
coefficient2 		P-value2 MAF3 Regression
coefficient3 		P-value3 MAF4 Regression
coefficient4 		P-value4
rs13053856 22q13.31 MIRNA7BHG 0.26 1.75 2.31E-06 0.25 0.33 1.09E-02 0.28 0.44 0.0314 - -
rs11090910 0.26 1.49 9.06E-06 0.24 0.30 2.14E-02 0.26 0.37 0.08 0.26 0.02 1.21E-02
rs11703832 0.20 1.56 2.88E-05 0.21 0.33 1.50E-02 0.26 0.28 0.20 0.20 0.03 2.60E-03
rs12170325 0.20 1.56 2.88E-05 0.21 0.33 1.50E-02 0.22 0.28 0.20 0.21 0.02 3.39E-02
1

Harvard Lung Cancer Study

2

the CARET study

3

Texas Lung Study

4

the ICARE study replication