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. 2015 Sep 29;9(5):054110. doi: 10.1063/1.4930983

FIG. 3.

FIG. 3.

Cell capture efficiency on aptamer functionalized microfluidic devices: (a) Representative bright field images of Caco-2 cells captured on EpCAM and nucleolin LNA aptamer functionalized surfaces of chips 1 and 2. (b) Comparison of capture efficiency of Caco-2 cells on aptamer and antibody modified surfaces. (c) Evaluation of capture specificity using FHs 74 Int cells on EpCAM LNA aptamer coated and non-coated surfaces. The results are represented as mean ± SEM obtained from three repeats, *** p ≤ 0.001. (d) Capture yield of 1000 Caco-2 cells flowed through EpCAM and nucleolin LNA aptamer functionalized chip 1 and chip 2 microchannels after each run for ten repeats. The results are represented as mean ±SEM obtained from three technical repeats, *** p ≤ 0.001, ** p ≤ 0.01, *p ≤ 0.05.