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. 2015 Sep 29;9(5):054110. doi: 10.1063/1.4930983

FIG. 5.

FIG. 5.

Capture efficiency of various cell lines and cancer stem-like cells on aptamer functionalized devices: (a) Representative bright field images of various cancer cells captured on EpCAM LNA aptamer (upper panel) and nucleolin LNA aptamer (middle panel) functionalized microchannels of chip 1. Arrowheads represent captured FHs 74 Int and RWPE-1 cells (blue) along with cancer cells. (b) Cancer cell capture based on EpCAM/nucleolin expression on aptamer functionalized chip 1. (c) Aptamer enabled capture of cancer stem-like cells on chip 1. Percentage EpCAM and nucleolin expression in various cell lines and cancer stem-like cells was estimated based on capture efficiency. Error bars represent standard deviation obtained from three repeats. (d) Cell viability post-capture on EpCAM LNA aptamer functionalized devices. Error bars represent standard deviation obtained from three repeats.