Table 2.
Joinpoint average percent change (APC)* and 95% confidence intervals (CI) for nodular sclerosis Hodgkin lymphoma incidence rates, by subtype and patient and tumor characteristics, 1992–2011, SEER (13 registries)
| Nodular sclerosis | ||||
|---|---|---|---|---|
| Not otherwise specified (9663‡) | Cellular phase, Grades 1 and
2 (9664–9667‡) |
|||
| N= 11,135 | N= 1,587 | |||
| Interval (yrs) | APC (95% CI) | Interval (yrs) | APC (95% CI) | |
| TOTAL | ||||
| 1992–2009 | 0.2 (−0.2, 0.6) | 1992–2004 | 2.1 (−0.8, 5) | |
| 2009–2011 | −8 (−18.1, 3.3) | 2004–2011 | −15 (−22.1, −7.2) | |
| Sex | ||||
| Male | 1992–2011 | 0.2 (−0.4, 0.7) | 1992–1994 | 38 (−6.6, 103.9) |
| 1994–2008 | −2.4 (−4.2, −0.7) | |||
| 2008–2011 | −34.1 (−49.9, −13.3) | |||
| Female | 1992–2011 | −0.6 (−1.2, 0.1) | 1992–2003 | 3.6 (0.4, 6.9) |
| 2003–2011 | −13.6 (−19.4, −7.4) | |||
| Race/ Ethnicity | ||||
| White | 1992–2007 | 0.6 (0.1, 1.1) | 1992–2004 | 2.4 (−0.6, 5.4) |
| 2007–2011 | −4.5 (−8.2, −0.6) | 2004–2011 | −14.6 (−22.2, −6.1) | |
| Black | 1992–2007 | 1.8 (0.6, 3) | 1992–2008 | 0.9 (−2.2, 4) |
| 2007–2011 | −8.1 (−15.7, 0) | 2008–2011 | −50.8 (−77.8, 9) | |
| Hispanic | 1992–2011 | 0.6 (−0.5, 1.7) | 1992–2011 | −2.9 (−6.2, 0.5) |
| API | 1992–2011 | 2.8 (0.8, 4.7) | 1992–2011 | −2.9 (−8.2, 2.8) |
| Age group (10 years) | ||||
| 00–09 years | 1992–2011 | 0.5 (−2.4, 3.5) | ||
| 10–19 years | 1992–2011 | −0.6 (−1.7, 0.5) | 1992–2011 | −2.5 (−5.2, 0.3) |
| 20–29 years | 1992–2011 | −0.4 (−1, 0.3) | 1992–2008 | −0.7 (−2.5, 1.2) |
| 2008–2011 | −40 (−60.7, −8.5) | |||
| 30–39 years | 1992–2007 | 0.7 (−0.3, 1.6) | 1992–2003 | 6.7 (2.2, 11.4) |
| 2007–2011 | −7.1 (−13.7, 0) | 2003–2011 | −17.7 (−25.3, −9.4) | |
| 40–49 years | 1992–2006 | 2.4 (1, 3.7) | 1992–2000 | 8.9 (−1.6, 20.5) |
| 2006–2011 | −7 (−12.7, −0.8) | 2000–2011 | −11.5 (−18.6, −3.7) | |
| 50–59 years | 1992–2011 | −1.7 (−3, −0.3) | 1992–2011 | −1.6 (−5.1, 1.9) |
| 60–69 years | 1992–2011 | −0.9 (−2.5, 0.7) | ||
| 70–79 years | 1992–2011 | 2 (0.2, 3.8) | ||
| 80+ years | 1992–2011 | 1.3 (−0.6, 3.2) | ||
| Age groups | ||||
| 00–14 years | 1992–2011 | −0.8 (−2.5, 1) | ||
| 15–39 years | 1992–2011 | −0.3 (−0.8, 0.1) | 1992–2008 | −0.3 (−2.4, 1.9) |
| 1992–2005 | 1.8 (0.5, 3.2) | 2008–2011 | −40.9 (−61.9, −8.2) | |
| 40–54 years | 2005–2011 | −5.5 (−9.4, −1.4) | 1992–1999 | 11.1 (1.6, 21.4) |
| 1999–2011 | −9.4 (−13.2, −5.4) | |||
| 55+ years | 1992–2011 | 0.3 (−0.6, 1.2) | 1992–2003 | 4 (−0.5, 8.7) |
| 2003–2011 | −15.9 (−21.8, −9.5) | |||
| Stage | ||||
| Localized | 1992–2011 | −3.5 (−4.5, −2.5) | ||
| Regional | 1992–2011 | 0.4 (−0.1, 0.8) | 1992–2004 | 2.3 (−0.1, 4.7) |
| 2004–2011 | −15.3 (−20.6, −9.5) | |||
| Distant | 1992–2011 | 1.5 (0.3, 2.7) | ||
| NA and unstaged | 1992–2011 | −0.5 (−2.9, 1.9) | ||
| Tumor site | ||||
| Nodal | 1992–2009 | 0.1 (−0.3, 0.5) | 1992–2004 | 2 (−1, 5.1) |
| 2009–2011 | −8.4 (−18.3, 2.7) | 2004–2011 | −15.1 (−21.5, −8.3) | |
| Extranodal | 1992–2011 | 2.3 (0.4, 4.2) | ||
| Registry | ||||
| Connecticut | 1992–2003 | 2.5 (0.7, 4.3) | 1992–2011 | −4.5 (−8.3, −0.5) |
| 2003–2011 | −6.3 (−9.2, −3.3) | |||
| Detroit | 1992–2011 | −0.4 (−1.8, 1.1) | 1992–2011 | −0.8 (−4.7, 3.2) |
| Hawaii | 1992–2011 | 1.8 (−0.7, 4.4) | ||
| Iowa | 1992–2011 | −0.1 (−1.1, 0.8) | 1992–2011 | −2.9 (−6.2, 0.6) |
| New Mexico | 1992–2011 | −3.1 (−5.1, −1) | ||
| Seattle | 1992–2011 | 1 (−0.3, 2.3) | −5.9 (−10.8, −0.7) | |
| Utah | 1992–2011 | 1.4 (0.1, 2.8) | ||
| Atlanta | 1992–2011 | −0.7 (−1.9, 0.6) | ||
| San Francisco- Oakland | 1992–2011 | −0.9 (−2.3, 0.5) | ||
| San Jose-Monterey | 1992–2011 | −0.4 (−1.9, 1.2) | ||
| Los Angeles | 1992–2011 | 0.2 (−0.7, 1.1) | 1992–2004 | 5.6 (1.2, 10.2) |
| 2004–2011 | −16 (−26.6, −3.9) | |||
| Alaska Natives | ||||
| Rural Georgia | ||||
‡
ICD-O-3 codes;
*
Joinpoint cannot process records when a dependent variablehas a value of 0.