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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Semin Cancer Biol. 2015 Jul 29;34:36–45. doi: 10.1016/j.semcancer.2015.07.004

Figure 2. Lymphoma evasion mechanisms undermine the immunosurveillance response.

Figure 2

1. NKG2D ligand shedding overwhelms NK cells leading to downregulated NKG2D and a hypofunctional phenotype and reduced CD58 expression may impair ability for missing self recognition. 2. Downregulation of MHC Class 1 molecules reduce Cytotoxic T Lymphocyte ability to identify tumor cells. 3. If DAMPs are not present, dendritic cells present antigen without costimulatory molecules promoting immune tolerance and regulatory T phenotypes. 4. Indoleamine 2,3-dioxygenase (IDO) expression on tumor and tolerogenic dendritic cells impairs CTL activity 5. TGFβ secretion and myeloid-derived suppressor cell (MDSC) activity further skews towards tolerogenic phenotypes.