Table 1.
Sample ID, H&E diagnoses (on section corresponding to VR-SIM imaging) and VR-SIM diagnoses for two pathology raters, # of image pixels, total imaging time in seconds, Gleason score, tumor content (%), and p63 status for all biopsies in cohorts 1 (labeled ‘A’) and 2 (labeled ‘B’). For VR-SIM diagnosis rank: 5 = most likely to be malignant, 4 = possibly malignant, 3 = indeterminate, 2 = possibly benign, 1 = most likely to be benign.
| Sample ID | # pixels (millions) | Image time (s) | Pathologist A H&E | Pathologist A VR-SIM | Pathologist B H&E | Pathologist B VR-SIM | Gleason score | Tumor content (%) | p63 |
|---|---|---|---|---|---|---|---|---|---|
| A1 | 205.8 | 24.5 | Mal | 5 | Mal | 5 | 3+3 | 8 | |
| A2 | 134.2 | 16 | Mal | 4 | Mal | 3 | 3+3 | 5 | |
| A3 | 210 | 25 | Nonmal | 2 | Nonmal | 2 | |||
| A4 | 294 | 35 | Nonmal | 3 | Nonmal | 2 | |||
| A5 | 210 | 25 | Nonmal | 3 | Nonmal | 1 | |||
| A6** | 588 | 72 | Nonmal | 2 | Mal | 3 | 3+3 | 5 | |
| A7 | 340.2 | 40.5 | Nonmal | 2 | Nonmal | 1 | |||
| A8 | 126 | 15 | Excluded due to misregistration between H&E section and VR-SIM image | ||||||
| A9 | 420 | 50 | Excluded due to misregistration between H&E section and VR-SIM image | ||||||
| A10 | 420 | 50 | Mal | 5 | Mal | 2 | 3+4 | 25 | |
| A11** | 205.8 | 24.5 | Mal | 4 | Nonmal | 2 | 3+3 | <5 | |
| A12 | 205.8 | 24.5 | Mal | 5 | Mal | 5 | 3+4 | 15 | |
| A13 | 205.8 | 24.5 | Mal | 5 | Mal | 4 | 3+3 | 15 | |
| A14 | 205.8 | 24.5 | Excluded due to misregistration between H&E section and VR-SIM image | ||||||
| A15 | 205.8 | 24.5 | Excluded due to misregistration between H&E section and VR-SIM image | ||||||
| A16 | 420 | 50 | Mal | 5 | Mal | 4 | 4+4 | 35 | |
| A17 | 340.2 | 40.5 | Mal | 5 | Mal | 4 | 3+3 | 8 | |
| A18 | 268.8 | 32 | Mal | 5 | Mal | 2 | 3+4 | 40 | |
| A19 | 205.8 | 24.5 | Mal | 5 | Mal | 5 | 3+4 | 45 | |
| A20 | 268.8 | 32 | Mal | 5 | Mal | 4 | 3+3 | 12 | |
| B1 | 420 | 50 | Nonmal | 3 | Nonmal | 2 | |||
| B2 | 340.2 | 40.5 | Nonmal | 1 | Nonmal | 2 | |||
| B3 | 340.2 | 40.5 | Nonmal | 2 | Nonmal | 3 | |||
| B4 | 268.8 | 32 | Nonmal | 2 | Nonmal | 3 | + | ||
| B5 | 105 | 12.5 | Nonmal | 1 | Nonmal | 2 | |||
| B6 | 420 | 50 | Mal | 4 | Mal | 4 | 3+3 | 1 | − |
| B7 | 205.8 | 24.5 | Nonmal | 1 | Nonmal | 2 | |||
| B8 | 205.8 | 24.5 | Nonmal | 1 | Nonmal | 2 | |||
| B9 | 205.8 | 24.5 | Mal | 1 | Mal | 2 | 3+3 | 1 | |
| B10 | 268.8 | 32 | Excluded due to misregistration between H&E section and VR-SIM image | ||||||
| B11 | 205.8 | 24.5 | Nonmal | 4 | Nonmal | 2 | |||
| B12 | 420 | 50 | Nonmal | 4 | Nonmal | 2 | |||
| B13 | 151.2 | 18 | Mal | 4 | Mal | 4 | 3+4 | 20 | |
| B14 | 268.8 | 32 | Nonmal | 1 | Nonmal | 2 | + | ||
| B15 | 268.8 | 32 | Nonmal | 4 | Nonmal | 2 | + | ||
| B16 | 205.8 | 24.5 | Mal | 4 | Mal | 2 | 3+3 | 12 | − |
| B17 | 268.8 | 32 | Mal | 2 | Mal | 5 | 4+3 | 75 | |
| B18 | 205.8 | 24.5 | Nonmal | 3 | Nonmal | 4 | + | ||
| B19 | 151.2 | 18 | Nonmal | 4 | Nonmal | 4 | |||
| B20 | 205.8 | 24.5 | Excluded due to misregistration between H&E section and VR-SIM image | ||||||
**
Indicates biopsies where the diagnosis of malignant or non-malignant differed between the two pathology raters on H&E.