Table 1. Participant Characteristics and Cancer Risk Factors by IF Methylation Among Cancer-Free Participants at Baseline.
| Mean ± SD / n(%) |
IFN | ICAM-1 | IL-6 | TLR2 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Low | High | Low | High | Low | High | Low | High | |||
| Age | 72.26 ± 6.84 | 72.1 ± 6.6 | 71.4 ± 6.8 | 71.6 ± 6.4 | 71.9 ± 7.1 | 71.8 ± 7.2 | 71.69 ± 6.3 | 71.5 ± 6.2 | 72.1 ± 7.0 | |
| p=0.17 | p=0.67 | p=0.80 | p=0.33 | |||||||
| Race | ||||||||||
| White | 766 (96%) | 271 (96.8%) | 266 (94.7%) | 208 (97.2%) | 204 (95.8%) | 273 (97.9%) | 262 (93.2%) | 226 (95.8%) | 212 (95.9%) | |
| Non-white | 29 (4%) | 9 (3.2%) | 15 (5.3%) | 6 (2.8%) | 9 (4.2%) | 6 (2.1%) | 19 (6.8%) | 10 (4.2%) | 9 (4.1%) | |
| p=0.30 | p=0.45 | p=0.01* | p=1.00 | |||||||
| Education | ||||||||||
| HS Grad or Less | 224 (28%) | 77 (27.5%) | 84 (29.9%) | 58 (27.1%) | 63 (29.6%) | 76 (27.2%) | 83 (29.5%) | 74 (31.4%) | 65 (29.4%) | |
| Some College/College Grad | 387 (49%) | 135 (48.2%) | 139 (49.5%) | 111 (51.9%) | 99 (46.5%) | 144 (51.6%) | 133 (47%) | 109 (43.2%) | 108 (48.9%) | |
| Any professional/graduate school | 184 (23%) | 68 (24.3%) | 58 (20.6%) | 45 (21.0%) | 51 (23.9%) | 59 (21.1%) | 65 (23.13%) | 53 (22.5%) | 48 (21.7%) | |
| p=0.56 | p=0.54 | p=0.61 | p=0.85 | |||||||
| BMI | 28.3 ± 4.1 | 28.3 ± 3.9 | 28.3 ± 4.4 | 28.5 ± 4.1 | 28.3 ± 4.4 | 28.6 ± 4.3 | 28.1 ± 3.9 | 28.5 ± 4.4 | 28.2 ± 4.0 | |
| p=0.92 | p=0.57 | p=0.15 | p=0.52 | |||||||
| Smoking Status | ||||||||||
| Never smoked | 227 (28.55%) | 90 (32.1%) | 66 (23.5%) | 58 (27.1%) | 60 (28.2%) | 74 (26.5%) | 80 (28.5%) | 60 (25.4%) | 65 (29.4%) | |
| Current Smoker | 33 (4%) | 10 (3.6%) | 16 (5.7%) | 10 (4.7%) | 11 (5.2%) | 12 (4.3%) | 13 (4.6%) | 12 (5.1%) | 8 (3.6%) | |
| Former Smoker | 535 (67%) | 180 (64.3%) | 199 (70.8%) | 146 (68.2%) | 142 (66.7%) | 193 (69.2%) | 188 (66.9%) | 164 (69.5%) | 148 (67.0%) | |
| p=0.05* | p=0.93 | p=0.87 | p=0.54 | |||||||
| Average Pack-Years | 21.5 ± 26.7 | 18.2 ± 24.2 | 23.4 ± 24.2 | 21.87 ± 24.9 | 22.05 ± 24.4 | 21.6 ± 24.5 | 19.7 ± 23.8 | 21.9 ± 24.3 | 20.4 ± 25.2 | |
| p=0.01* | p=0.94 | p=0.35 | p=0.51 | |||||||
| Alcohol Consumption | ||||||||||
| 0-1 average drinks/day | 644 (81%) | 237 (84.6%) | 224 (79.7%) | 170 (79.4%) | 172 (80.8%) | 232 (83.2%) | 228 (81.1%) | 195 (82.6%) | 179 (81.0%) | |
| 2+ average drinks/day | 151 (19%) | 43 (15.4%) | 57 (20.3%) | 44 (20.6%) | 41 (19.3%) | 47 (16.9%) | 53 (18.9%) | 41 (17.4%) | 42 (19.0%) | |
| p=0.15 | p=0.81 | p=0.58 | p=0.72 | |||||||
| White Blood Cell Count | 6.5 ± 3.25 | 6.1 ± 1.4 | 6.7 ± 2.8 | 6.5 ± 1.7 | 6.4 ± 2.9 | 6.5 ± 1.7 | 5.2 ± 1.5 | 6.5 ± 2.8 | 6.2 ± 1.6 | |
| p=0.006* | p=0.78 | p=0.07 | p=0.12 | |||||||
| Proportion Neutrophils | 61.9 ± 8.7 | 59.3 ± 6.9 | 64.9 ± 8.3 | 62.5 ± 8.2 | 62.1 ± 8.6 | 62.3 ± 8.1 | 61.9 ± 7.9 | 62.8 ± 8.7 | 61.3 ± 7.7 | |
| p<0.001* | p=0.64 | p=0.54 | p=0.06 | |||||||
*
= Statistically significant at p<0.05; p-values shown for Student’s t-test and Fischer’s Exact test for continuous and categorical characteristics, respectively