Table 3.

Univariate and multivariate Cox proportional analysis regarding overall survival

	Univariate analysis		Multivariate analysis
Parameter	HR (95 % CI)	P-value	HR (95 % CI)	P-value
Age at operation(years)
<65	1 (referent)	0.220	1 (referent)	0.219
≥65	1.70(0.73-4.00)		2.06(0.65-6.49)
Gender
Female	1 (referent)	0.772	1 (referent)	0.615
Male	1.09(0.62-1.89)		1.20(0.59-2.45)
Performance status
0 ~ 1	1 (referent)	0.006	1 (referent)	0.975
≥2	2.22 (1.26-3.93)		0.99 (0.48-2.03)
Diabetes mellitus
No	1 (referent)	0.943	1 (referent)	0.218
Yes	1.07(0.15-7.78)		0.27(0.03-2.18)
Cardiopulmonary disease
No	1 (referent)	0.344	1 (referent)	0.342
Yes	0.38(0.06-2.78)		0.33(0.03-3.27)
Ever smoked
No	1 (referent)	0.579	1 (referent)	0.273
Yes	1.23(0.60-2.52)		1.69 (0.66-4.32)
Tumor depth
Superficial	1 (referent)	<0.001	1 (referent)	0.096
Deep	6.09 (2.74-13.53)		2.41(0.85-6.77)
Tumor grade
G1	1 (referent)	0.002	NA	NA
G2	4.66(1.78-12.22)	<0.001
G3	9.27(3.16-27.20)
Tumor size
<5 cm	1 (referent)	0.001	NA	NA
≥5 cm	2.87(1.55-5.32)
Tumor site
Trunk&extremity	1 (referent)	<0.001	1 (referent)	0.002
head/neck&intra-abdominal	4.48(2.57-7.81)		3.14 (1.52-6.48)
AJCC stage
IA + IB	1 (referent)	0.001	1 (referent)	0.002
IIA + IIB	5.13(1.97-13.37)	<0.001	3.92 (1.43-10.76)	0.008
III + IV	10.56 (3.71-30.08)		7.45(2.44-22.81)
Adjuvant radiotherapy
Yes	1 (referent)	0.798	1 (referent)	0.692
No	1.08 (0.60-1.95)		0.86(0.40-1.84)
Adjuvant chemocherapy
Yes	1 (referent)	0.320	1 (referent)	0.929
No	1.44 (0.70-2.97)		1.04(0.45-2.41)
PLR
<133.915z	1 (referent)	0.002	1 (referent)	0.019
≥133.915	2.49 (1.41-4.39)		2.60(1.17-5.74)
NLR
<2.5	1 (referent)	<0.001	1 (referent)	0.881
≥2.5	2.83 (1.61-4.99)		1.06(0.52-2.16)

Bold print indicates statistical significance