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. 2015 Sep 28;11(9):828. doi: 10.15252/msb.20156505

Figure 4.

Figure 4

Evidence for hyperploidy being a risk factor for chromothripsis in SHH-type medulloblastoma

  1. Oscillating copy number states and SRs on chromosome 14 in MB34 (based on WGS data), resulting from chromothripsis. SRs are color-coded: red, deletion type (T-H); green, duplication type (H-T); blue, head-to-head (H-H) type; purple, tail-to-tail (T-T) type; gray, inter-chromosomal.
  2. Copy number jump distribution for chromosome 14 in MB34, with diagonal points indicating chromothripsis occurred on a previously unrearranged chromosome.
  3. Distribution of copy number segment switches for chromosome 14 in MB34.
  4. Oscillating copy number states and SRs on chromosome 15 in MB243 (based on WGS data), resulting from chromothripsis and BFBs.
  5. Copy number jump distribution for chromosome 15 in MB243, with off-diagonal points indicating chromothripsis occurred on a previously rearranged chromosome.
  6. Distribution of copy number segment switches for chromosome 15 in MB243.