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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Curr Opin Pulm Med. 2015 Sep;21(5):454–462. doi: 10.1097/MCP.0000000000000191

Figure 1.

Figure 1

An overview of epigenetic regulation of gene expression in IPF lung. Environmental exposures such as cigarette smoke and genetic variants are associated with changes in epigenetic marks which in turn are associated with altered gene expression. Because the causative nature of these associations has not been established, these molecular processes are drawn as a circle with no arrows. * symbols on the chromosome view plot indicate approximate location of IPF-associated genetic loci from the two published GWAS (Fingerlin. Nat Genet. 2013;45:613–20 and Noth. Lancet Resp Med. 2013;1:309–17).